What are the proven methods to promote learning in synchronous and asynchronous e-learning? Which learning environment is best: classroom, synchronous e-learning, or asynchronous e-learning? What does research tell us about the best use of visuals, text, and audio to promote learning? What are learning agents and how do they facilitate deeper learning? What makes a simulation or game effective? Based on more than 25 years of research on multimedia learning, the speaker will present the guidelines, the evidence, and application examples to address these questions.